Science
Women's wellness,
made with heart
Our why
Feeling better starts in your gut
A majority of women deal with iron or gut issues, and most of us spend a lifetime searching for answers and relief. We’ve been there. Fatigue. Bloating. Dizziness. Tummy drama. Thinning hair. When we finally found what worked for us, we had to share it with you, too.
THE SCIENCE
Ingredients backed by 16 human clinical studies
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Peterson 2025 (immunogenicity RCT, healthy adults) — Adults taking effera™ developed no antibodies against the protein; those taking bovine lactoferrin did. Well-tolerated up to 3.4 g/day.
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Peterson 2026 (microbiome RCT, healthy adults) — Raised fecal acetate and increased Faecalibacterium and Lachnospira without altering overall gut diversity.
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Evans 2026 (case series, active women with persistent low iron) — 100 mg/day raised ferritin and serum iron, with no GI side effects reported.
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Zhuang 2026 (pilot, adults consuming whey protein) — Increased BCAA absorption, reduced intestinal permeability, and improved grip strength and muscle mass, with the largest effects in older adults.
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Lin 2023 (RCT, healthy adults) — Increased arginine bioavailability by 17.3% and the Arg/ADMA ratio by 167%.
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Lin 2023 (pilot, adults with ulcerative colitis) — Three months improved intestinal barrier function and increased Faecalibacterium prausnitzii by 420%.
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Madempudi 2019 (RCT, adults with IBS) — Reduced abdominal pain, bloating, urgency, straining, gas, and improved stool consistency.
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Madempudi 2020 (RCT, adults with functional constipation) — Increased complete spontaneous bowel movements and improved stool consistency.
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LeMoire 2025 (RCT, healthy adults with infrequent bowel movements) — Improved stool form and frequency.
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Sudha & Bhonagiri 2012 (adults with acute diarrhea) — Reduced episode frequency from ~8 to under 1 per day and improved stool consistency.
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Venkataraman 2023 (RCT, adults with functional constipation) — Adding IS-2 to lactulose shortened time to symptom relief versus lactulose alone.
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Bamola 2022 (RCT, adults with IBD on standard therapy) — Reduced disease severity and improved physical and psychological symptom scores.
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Ratna Sudha 2012 (clinical study, women with bacterial vaginosis) — Added to standard antimicrobial therapy, raised resolution rate from 45% to 80%.
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Jariyal 2022 (RCT, resistance-trained adults consuming whey protein) — Increased plasma amino acid levels and improved muscle strength.
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Ratna Sudha 2011 (clinical study, adults with elevated cholesterol) — Improved lipid profiles.
effera™ Lactoferrin
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Peterson 2025 (immunogenicity RCT, healthy adults) — Adults taking effera™ developed no antibodies against the protein; those taking bovine lactoferrin did. Well-tolerated up to 3.4 g/day.
- READ NOW → Opens in a new window.
Peterson 2026 (microbiome RCT, healthy adults) — Raised fecal acetate and increased Faecalibacterium and Lachnospira without altering overall gut diversity.
- READ NOW → Opens in a new window.
Evans 2026 (case series, active women with persistent low iron) — 100 mg/day raised ferritin and serum iron, with no GI side effects reported.
AstraGin®
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Zhuang 2026 (pilot, adults consuming whey protein) — Increased BCAA absorption, reduced intestinal permeability, and improved grip strength and muscle mass, with the largest effects in older adults.
- READ NOW → Opens in a new window.
Lin 2023 (RCT, healthy adults) — Increased arginine bioavailability by 17.3% and the Arg/ADMA ratio by 167%.
- READ NOW → Opens in a new window.
Lin 2023 (pilot, adults with ulcerative colitis) — Three months improved intestinal barrier function and increased Faecalibacterium prausnitzii by 420%.
Bacillus coagulans Unique IS-2®
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Madempudi 2019 (RCT, adults with IBS) — Reduced abdominal pain, bloating, urgency, straining, gas, and improved stool consistency.
- READ NOW → Opens in a new window.
Madempudi 2020 (RCT, adults with functional constipation) — Increased complete spontaneous bowel movements and improved stool consistency.
- READ NOW → Opens in a new window.
LeMoire 2025 (RCT, healthy adults with infrequent bowel movements) — Improved stool form and frequency.
- READ NOW → Opens in a new window.
Sudha & Bhonagiri 2012 (adults with acute diarrhea) — Reduced episode frequency from ~8 to under 1 per day and improved stool consistency.
- READ NOW → Opens in a new window.
Venkataraman 2023 (RCT, adults with functional constipation) — Adding IS-2 to lactulose shortened time to symptom relief versus lactulose alone.
- READ NOW → Opens in a new window.
Bamola 2022 (RCT, adults with IBD on standard therapy) — Reduced disease severity and improved physical and psychological symptom scores.
- READ NOW → Opens in a new window.
Ratna Sudha 2012 (clinical study, women with bacterial vaginosis) — Added to standard antimicrobial therapy, raised resolution rate from 45% to 80%.
- READ NOW → Opens in a new window.
Jariyal 2022 (RCT, resistance-trained adults consuming whey protein) — Increased plasma amino acid levels and improved muscle strength.
- READ NOW → Opens in a new window.
Ratna Sudha 2011 (clinical study, adults with elevated cholesterol) — Improved lipid profiles.
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Colostrum Benefits: What The Research Actually ShowsLearn proven colostrum benefits for gut and immunity with real clinical data. Buy high-quality formulas at Palisade to support your daily wellness today.
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Lactoferrin Benefits: What The Science ShowsLearn the real lactoferrin benefits backed by clinical research. See why Palisade's gummies support gut and iron health. Shop now.
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Best Time To Take Colostrum: Morning Or Night?Wondering when the best time to take colostrum is? Palisade breaks down morning vs. night dosing for gut health. Shop lactoferrin gummies today.
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